nuke it from orbit

Etymology
Alteration of dialog from the 1986 movie  in which Ripley proposes a solution to an infestation of dangerous creatures: "I say we take off and nuke the entire site from orbit. It's the only way to be sure."

Verb

 * 1)  The referent of it is dangerous or undesirable and should be eliminated.

Usage notes

 * Usually used as a commentary on the merits of the thing to be nuked rather than as a call to action.
 * In information security, implies that a system has been so thoroughly compromised that the only choice is to completely recreate it.